ATM

Across TCGA cell cohorts, ATM RNA expression is significantly associated with the go_rna of many other GO terms, with 4,615 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ATM-associated GO terms across cancer lineages are Pre-B cell allelic exclusion, Peptidyl-serine autophosphorylation, and Positive regulation of telomere maintenance. Each is linked with ATM in more than 19 cancer types. Because this analysis shows association rather than direction, both ATM-to-partner and partner-to-ATM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pre-B cell allelic exclusion grouped by ATM-low versus ATM-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATM→partner) and Y-score (partner→ATM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Pre-B cell allelic exclusion →	+1.092	+1.036	<.001	<.001	3	20
BLOOD_Myeloma	Peptidyl-serine autophosphorylation →	+0.172	+0.886	<.001	.001	3	19
UPPER_AERODIGESTIVE_TRACT	Positive regulation of telomere maintenance →	+0.090	+1.394	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Non-motile cilium assembly →	+0.072	+0.904	.002	.003	3	16
UPPER_AERODIGESTIVE_TRACT	Positive regulation of chromosome organization →	+0.100	+1.248	.001	.002	3	15
UPPER_AERODIGESTIVE_TRACT	Centrosome cycle →	+0.081	+1.292	.002	.002	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,615 associations by consensus.

Pre-B cell allelic exclusion by ATM expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →