ATM

Across TCGA cell cohorts, ATM mutation is significantly associated with the RNA expression of many other genes, with 491 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ATM-associated genes across cancer lineages are EBF2, DPEP3, and FAM236A. Each is linked with ATM in more than 2 cancer types. Because this analysis shows association rather than direction, both ATM-to-partner and partner-to-ATM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EBF2 grouped by ATM-low versus ATM-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATM→partner) and Y-score (partner→ATM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EBF2 →	+0.105	+2.229	.005	.001	3	3
SOFT_TISSUE	DPEP3 →	+0.322	+3.637	<.001	.002	3	2
SOFT_TISSUE	FAM236A →	+0.033	+3.977	<.001	.007	3	2
KIDNEY	ZNF479 →	+0.601	+2.954	.002	.005	3	2
BLOOD_Leukemia	ZNF705D →	+0.028	+2.121	.003	.007	3	2
LUNG_SCLC	TXNDC2 →	+0.237	+3.603	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 491 associations by consensus.

EBF2 by ATM expression — BLOOD_Leukemia

Explore this box plot interactively →