ATL2

Across TCGA patient cohorts, ATL2 mutation is significantly associated with the RNA expression of many other genes, with 1,878 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATL2-associated genes across cancer lineages are RNU6-458P, MIR649, and RNA5SP420. Each is linked with ATL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATL2-to-partner and partner-to-ATL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-458P grouped by ATL2-low versus ATL2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATL2→partner) and Y-score (partner→ATL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RNU6-458P →	+0.175	+5.417	<.001	.001	3	2
STAD	MIR649 →	+0.462	+3.403	.002	.006	3	2
UCEC	RNA5SP420 →	+0.444	+2.189	.002	.002	3	2
CESC	S100A7L2 →	+0.115	+5.010	<.001	.009	3	1
CESC	RPL23AP39 →	+0.087	+5.201	.001	.007	3	1
CESC	RNA5SP294 →	+0.298	+5.103	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,878 associations by consensus.

RNU6-458P by ATL2 expression — STAD

Explore this box plot interactively →