ATIC

Across TCGA patient cohorts, ATIC RNA expression is significantly associated with the RNA expression of many other genes, with 19,281 significant associations in total. ACC shows the largest number of these associations.

The most reproducible ATIC-associated genes across cancer lineages are MRPS5, PSMD1, and VARS1. Each is linked with ATIC in more than 33 cancer types. Because this analysis shows association rather than direction, both ATIC-to-partner and partner-to-ATIC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ATIC versus MRPS5 in ACC, with a Pearson correlation of 0.90.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATIC→partner) and Y-score (partner→ATIC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	MRPS5 →	+1.156	+1.180	<.001	<.001	3	34
ACC	PSMD1 →	+1.363	+1.122	<.001	<.001	3	34
ACC	VARS1 →	+0.853	+1.005	<.001	<.001	3	34
ACC	FARSB →	+1.223	+1.172	<.001	<.001	3	34
ACC	CPSF3 →	+0.980	+1.133	<.001	<.001	3	34
ACC	WDR12 →	+1.052	+1.183	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,281 associations by consensus.

ATIC vs MRPS5 — ACC

Explore this scatter interactively →