ATIC

Across TCGA patient cohorts, ATIC protein abundance is significantly associated with the RNA expression of many other genes, with 9,601 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible ATIC-associated genes across cancer lineages are STK16, WDR12, and NIF3L1. Each is linked with ATIC in more than 5 cancer types. Because this analysis shows association rather than direction, both ATIC-to-partner and partner-to-ATIC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ATIC versus STK16 in OV, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATIC→partner) and Y-score (partner→ATIC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	STK16 →	+0.359	+0.288	<.001	<.001	3	6
OV	WDR12 →	+0.633	+0.429	<.001	<.001	3	5
OV	NIF3L1 →	+0.624	+0.468	<.001	<.001	3	5
OV	RPE →	+0.632	+0.374	<.001	.002	3	5
UCEC	FARSB →	+0.479	+0.326	<.001	<.001	3	5
PDAC	FPR2 →	-1.304	-0.285	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,601 associations by consensus.

ATIC vs STK16 — OV

Explore this scatter interactively →