ATG9B

Across TCGA patient cohorts, ATG9B mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATG9B-associated genes across cancer lineages are p27, EGFR_pY1068, and ERK2. Each is linked with ATG9B in more than 1 cancer types. Because this analysis shows association rather than direction, both ATG9B-to-partner and partner-to-ATG9B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27 grouped by ATG9B-low versus ATG9B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG9B→partner) and Y-score (partner→ATG9B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27 →	+0.181	+2.000	.039	.030	3	2
UCEC	EGFR_pY1068 →	-0.280	-2.415	.005	.003	3	1
UCEC	ERK2 →	+0.252	+1.906	.001	.016	3	1
UCEC	ETS-1 →	+0.359	+2.321	.005	.034	3	1
UCEC	GATA6 →	-0.128	-2.584	.039	.010	3	1
UCEC	JNK2 →	+0.245	+3.331	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

p27 by ATG9B expression — UCEC

Explore this box plot interactively →