ATG5

Across TCGA patient cohorts, ATG5 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATG5-associated genes across cancer lineages are Heregulin, JNK_pT183_Y185, and Ku80. Each is linked with ATG5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATG5-to-partner and partner-to-ATG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by ATG5-low versus ATG5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG5→partner) and Y-score (partner→ATG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.137	-3.321	.021	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.208	-3.000	.010	.036	3	1
UCEC	Ku80 →	+0.354	+3.183	.001	.009	3	1
UCEC	STAT3_pY705 →	-0.410	-3.159	.001	.019	3	1
UCEC	Tuberin →	+0.327	+2.179	.012	.034	3	1
UCEC	Caspase-8 →	-0.320	-3.584	.008	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Heregulin by ATG5 expression — UCEC

Explore this box plot interactively →