ATG5

Across TCGA pan-cancer cohorts, ATG5 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ATG5’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ATG5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ATG5 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and KICH are the cancer types where ATG5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATG5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.993	<.001	12	view →
THCA	Male	III,IV	−0.521	<.001	10	view →
KICH	Female	All	−1.281	<.001	8	view →
BLCA	All	All	+0.389	.001	8	view →
STAD	All	II,III,IV	+0.566	.001	6	view →
KIRC	All	II,III,IV	−0.347	<.001	6	view →
LUSC	All	All	+0.391	<.001	5	view →
ESCA	All	II,III,IV	+0.855	.039	3	view →
LIHC	Male	All	+0.309	.015	3	view →
CHOL	All	All	+0.844	.005	2	view →
PRAD	All	All	−0.416	.002	2	view →
BRCA	All	II,III,IV	+0.141	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ATG5–HNSC

Open the HNSC breakdown →