ATG5

Across TCGA cell cohorts, ATG5 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATG5-associated genes across cancer lineages are SSMEM1 and LRRC3C. Each is linked with ATG5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATG5-to-partner and partner-to-ATG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSMEM1 grouped by ATG5-low versus ATG5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG5→partner) and Y-score (partner→ATG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SSMEM1 →	+0.023	+3.707	.008	.009	3	1
LARGE_INTESTINE	LRRC3C →	+0.352	+3.777	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

SSMEM1 by ATG5 expression — LARGE_INTESTINE

Explore this box plot interactively →