ATG4D

Across TCGA patient cohorts, ATG4D mutation is significantly associated with the RNA expression of many other genes, with 696 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATG4D-associated genes across cancer lineages are RPL12P5, SNORD90, and PKN3. Each is linked with ATG4D in more than 2 cancer types. Because this analysis shows association rather than direction, both ATG4D-to-partner and partner-to-ATG4D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL12P5 grouped by ATG4D-low versus ATG4D-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG4D→partner) and Y-score (partner→ATG4D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPL12P5 →	+0.124	+3.357	.003	.006	3	3
BRCA	SNORD90 →	+0.270	+3.747	<.001	.005	3	2
UCEC	PKN3 →	+0.758	+3.332	.004	.005	3	2
LGG	RNU6-1298P →	+0.339	+7.977	<.001	.007	3	2
UCEC	POLH-AS1 →	+0.789	+3.329	<.001	.005	3	2
UCEC	MKRN2OS →	+0.789	+3.332	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 696 associations by consensus.

RPL12P5 by ATG4D expression — COAD

Explore this box plot interactively →