ATG4D

Across TCGA pan-cancer cohorts, ATG4D RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ATG4D’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where ATG4D RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ATG4D is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

LUSC, LIHC, and HNSC are the cancer types where ATG4D tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATG4D RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	II,III,IV	+1.047	<.001	8	view →
LIHC	Female	II,III,IV	+1.193	<.001	7	view →
HNSC	Male	IV	+0.687	.002	7	view →
UCEC	All	III,IV	+1.088	<.001	6	view →
KICH	Female	II,III,IV	+1.011	<.001	6	view →
BRCA	All	III,IV	+0.722	<.001	6	view →
KIRC	Male	II,III,IV	−0.465	<.001	6	view →
CHOL	Female	All	+2.513	<.001	5	view →
COAD	Male	All	−0.534	<.001	5	view →
STAD	All	II,III,IV	+0.602	.005	4	view →
THCA	Male	II,III,IV	−0.474	.002	4	view →
READ	All	All	−0.473	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ATG4D–LUSC

Open the LUSC breakdown →