ATG4D

Across TCGA patient cohorts, ATG4D mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATG4D-associated genes across cancer lineages are ACC1, Ku80, and Annexin-1. Each is linked with ATG4D in more than 1 cancer types. Because this analysis shows association rather than direction, both ATG4D-to-partner and partner-to-ATG4D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by ATG4D-low versus ATG4D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG4D→partner) and Y-score (partner→ATG4D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.608	+3.013	.001	.018	3	1
UCEC	Ku80 →	+0.361	+2.179	.003	.034	3	1
UCEC	Annexin-1 →	+0.695	+2.827	.011	.035	3	1
UCEC	4E-BP1 →	+0.434	+3.029	.002	.018	2	2
COAD	PREX1 →	+0.281	+3.025	.009	.019	3	1
COAD	PTEN →	+0.155	+3.008	.033	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ACC1 by ATG4D expression — UCEC

Explore this box plot interactively →