ATG4D

Across TCGA cell cohorts, ATG4D RNA expression is significantly associated with the go_rna of many other GO terms, with 4,674 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ATG4D-associated GO terms across cancer lineages are Protein localization to phagophore assembly site, Positive regulation of anaphase-promoting complex-dependent catabolic process, and Energy coupled proton transmembrane transport, against electrochemical gradient. Each is linked with ATG4D in more than 14 cancer types. Because this analysis shows association rather than direction, both ATG4D-to-partner and partner-to-ATG4D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to phagophore assembly site grouped by ATG4D-low versus ATG4D-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG4D→partner) and Y-score (partner→ATG4D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Protein localization to phagophore assembly site →	+0.134	+0.877	<.001	<.001	3	15
BONE	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.124	+0.585	<.001	.001	3	13
OESOPHAGUS	Energy coupled proton transmembrane transport, against electrochemical gradient →	+0.091	+0.690	<.001	<.001	3	11
OESOPHAGUS	Electron transport coupled proton transport →	+0.091	+0.690	<.001	<.001	3	11
URINARY_TRACT	Regulation of protein localization to chromatin →	+0.130	+0.706	.001	.004	3	11
BONE	Positive regulation of DNA metabolic process →	+0.070	+0.785	.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,674 associations by consensus.

Protein localization to phagophore assembly site by ATG4D expression — BREAST

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