ATG4C

Across TCGA pan-cancer cohorts, ATG4C Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ATG4C data layer compared with 22 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ATG4C Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ATG4C expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, DLBC, and LAML are the cancer types where ATG4C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.625	.005	36	view →
DLBC	OS	Median	II,III,IV	0.172	0.949	<.001	18	view →
LAML	DFS	Median	All	0.140	0.572	.040	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
LUSC	DFS	Median	All	0.136	0.791	.005	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ATG4C–UCEC (DFS)

Open the UCEC breakdown →