ATG4C

Across TCGA pan-cancer cohorts, ATG4C RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ATG4C’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ATG4C RNA is repressed in tumor relative to normal tissue. In most cancer types ATG4C is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LIHC are the cancer types where ATG4C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATG4C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.125	<.001	11	view →
KICH	Female	All	−1.457	<.001	10	view →
LIHC	Male	II,III,IV	+0.757	<.001	8	view →
HNSC	Female	All	+0.616	<.001	8	view →
KIRP	All	All	−0.405	<.001	7	view →
STAD	All	II,III,IV	+0.586	<.001	4	view →
LUSC	Male	II,III,IV	−0.438	.004	4	view →
CHOL	Female	All	+1.093	<.001	3	view →
BRCA	Female	All	−0.174	.004	3	view →
UCEC	All	All	−0.628	.005	2	view →
BLCA	Female	All	+0.551	.038	2	view →
KIRC	All	All	+0.206	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ATG4C–THCA

Open the THCA breakdown →