ATG4C

Across TCGA patient cohorts, ATG4C mutation is significantly associated with the RNA expression of many other genes, with 2,890 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATG4C-associated genes across cancer lineages are RPL17P12, LINC02558, and HNRNPH1P2. Each is linked with ATG4C in more than 1 cancer types. Because this analysis shows association rather than direction, both ATG4C-to-partner and partner-to-ATG4C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL17P12 grouped by ATG4C-low versus ATG4C-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG4C→partner) and Y-score (partner→ATG4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPL17P12 →	+0.041	+4.328	<.001	.007	3	2
SKCM	LINC02558 →	+0.113	+4.224	<.001	.002	3	2
CESC	HNRNPH1P2 →	+0.062	+5.060	<.001	.001	3	2
BRCA	RNA5SP23 →	+0.381	+7.731	<.001	.009	3	2
UCEC	MIR6803 →	+0.076	+3.777	<.001	.007	3	2
UCEC	MIA-RAB4B →	+0.046	+1.448	.005	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,890 associations by consensus.

RPL17P12 by ATG4C expression — SKCM

Explore this box plot interactively →