ATG4C

Across TCGA patient cohorts, ATG4C mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATG4C-associated genes across cancer lineages are EGFR_pY1068, FoxM1, and INPP4B. Each is linked with ATG4C in more than 1 cancer types. Because this analysis shows association rather than direction, both ATG4C-to-partner and partner-to-ATG4C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ATG4C-low versus ATG4C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG4C→partner) and Y-score (partner→ATG4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.253	-2.115	.006	.016	3	1
UCEC	FoxM1 →	+0.188	+2.247	.048	.001	3	1
UCEC	INPP4B →	-0.273	-1.807	.021	.025	3	1
UCEC	MEK1 →	+0.444	+3.000	<.001	<.001	3	1
UCEC	Notch1 →	+0.157	+3.594	.002	.001	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.442	-1.807	.007	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

EGFR_pY1068 by ATG4C expression — UCEC

Explore this box plot interactively →