ATG4C

Across TCGA cell cohorts, ATG4C RNA expression is significantly associated with the go_rna of many other GO terms, with 3,946 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ATG4C-associated GO terms across cancer lineages are Positive regulation of centriole replication, Regulation of DNA damage checkpoint, and Protein delipidation. Each is linked with ATG4C in more than 14 cancer types. Because this analysis shows association rather than direction, both ATG4C-to-partner and partner-to-ATG4C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of centriole replication grouped by ATG4C-low versus ATG4C-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG4C→partner) and Y-score (partner→ATG4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of centriole replication →	+0.146	+0.872	<.001	<.001	3	15
OVARY	Regulation of DNA damage checkpoint →	+0.107	+0.874	<.001	<.001	3	14
BLOOD_Myeloma	Protein delipidation →	+0.139	+1.008	.001	<.001	3	14
LIVER	Regulation of chromosome condensation →	+0.152	+0.512	<.001	.001	3	14
UPPER_AERODIGESTIVE_TRACT	Positive regulation of chromosome condensation →	+0.226	+0.656	<.001	.003	2	14
UPPER_AERODIGESTIVE_TRACT	Mitotic G2/M transition checkpoint →	+0.116	+0.803	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,946 associations by consensus.

Positive regulation of centriole replication by ATG4C expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →