ATG4C

Across TCGA cell cohorts, ATG4C mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATG4C-associated genes across cancer lineages are CRP, LYZL2, and IFNL2. Each is linked with ATG4C in more than 1 cancer types. Because this analysis shows association rather than direction, both ATG4C-to-partner and partner-to-ATG4C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRP grouped by ATG4C-low versus ATG4C-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG4C→partner) and Y-score (partner→ATG4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CRP →	+0.086	+5.029	<.001	.006	3	1
LUNG_SCLC	LYZL2 →	+0.026	+5.643	<.001	.002	3	1
LUNG_SCLC	IFNL2 →	+0.038	+5.029	<.001	.006	3	1
LARGE_INTESTINE	BPIFB6 →	+0.016	+4.022	<.001	.006	3	1
LARGE_INTESTINE	RNASE8 →	+0.042	+3.345	<.001	.007	3	1
LARGE_INTESTINE	HSF5 →	+0.031	+4.000	.006	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

CRP by ATG4C expression — LUNG_SCLC

Explore this box plot interactively →