ATG4B

Across TCGA patient cohorts, ATG4B mutation is significantly associated with the RNA expression of many other genes, with 1,257 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATG4B-associated genes across cancer lineages are RNU6-226P, EML2-AS1, and BAG3. Each is linked with ATG4B in more than 1 cancer types. Because this analysis shows association rather than direction, both ATG4B-to-partner and partner-to-ATG4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-226P grouped by ATG4B-low versus ATG4B-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG4B→partner) and Y-score (partner→ATG4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-226P →	+0.626	+3.822	.002	.009	3	2
UCEC	EML2-AS1 →	+0.058	+1.454	<.001	.001	3	2
UCEC	BAG3 →	+0.446	+1.736	.001	.007	3	2
UCEC	C18orf25 →	+0.291	+1.332	.007	.003	3	2
UCEC	ZDHHC7 →	+0.262	+1.676	.007	.003	3	2
UCEC	TYW3 →	+0.300	+1.950	.004	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,257 associations by consensus.

RNU6-226P by ATG4B expression — LUAD

Explore this box plot interactively →