ATG4B

Across TCGA pan-cancer cohorts, ATG4B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ATG4B’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ATG4B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ATG4B is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

COAD, KICH, and LIHC are the cancer types where ATG4B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATG4B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+0.743	<.001	10	view →
KICH	Male	All	−1.039	<.001	9	view →
LIHC	Female	II,III,IV	+0.989	<.001	9	view →
THCA	Male	IV	−0.583	<.001	9	view →
STAD	Male	II,III,IV	+0.972	<.001	8	view →
HNSC	Male	IV	+0.692	<.001	8	view →
UCEC	All	All	+0.446	<.001	6	view →
CHOL	Male	All	+2.135	<.001	5	view →
LUSC	Male	All	+0.336	<.001	3	view →
ESCA	All	All	+0.673	.004	2	view →
KIRP	All	IV	+0.629	.037	2	view →
READ	Female	All	+0.431	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ATG4B–COAD

Open the COAD breakdown →