ATG4B

Across TCGA patient cohorts, ATG4B mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATG4B-associated genes across cancer lineages are INPP4B, MEK1, and 14-3-3_beta. Each is linked with ATG4B in more than 1 cancer types. Because this analysis shows association rather than direction, both ATG4B-to-partner and partner-to-ATG4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by ATG4B-low versus ATG4B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG4B→partner) and Y-score (partner→ATG4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.226	-2.247	.024	.001	3	2
UCEC	MEK1 →	+0.304	+2.070	.007	.001	3	2
UCEC	14-3-3_beta →	-0.071	-2.195	.022	.009	3	1
UCEC	eEF2 →	+0.360	+2.087	.001	.004	3	1
UCEC	EGFR_pY1068 →	-0.286	-1.893	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.147	-3.000	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

INPP4B by ATG4B expression — UCEC

Explore this box plot interactively →