ATG4B

Across TCGA cell cohorts, ATG4B RNA expression is significantly associated with the go_rna of many other GO terms, with 3,726 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ATG4B-associated GO terms across cancer lineages are Otolith mineralization, COP9 signalosome assembly, and Chromosome separation. Each is linked with ATG4B in more than 18 cancer types. Because this analysis shows association rather than direction, both ATG4B-to-partner and partner-to-ATG4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Otolith mineralization grouped by ATG4B-low versus ATG4B-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG4B→partner) and Y-score (partner→ATG4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Otolith mineralization →	+0.154	+0.993	.001	<.001	3	19
LUNG_NSCLC_LUSC	COP9 signalosome assembly →	+0.215	+0.920	<.001	<.001	3	14
KIDNEY	Chromosome separation →	+0.104	+0.665	.008	.008	2	15
LARGE_INTESTINE	DNA replication-dependent chromatin disassembly →	+0.106	+0.577	<.001	.004	3	13
OVARY	Positive regulation of organelle assembly →	+0.050	+0.657	.003	.001	3	13
UPPER_AERODIGESTIVE_TRACT	Phosphatidylinositol biosynthetic process →	+0.065	+0.789	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,726 associations by consensus.

Otolith mineralization by ATG4B expression — BONE

Explore this box plot interactively →