ATG4B

Across TCGA cell cohorts, ATG4B mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ATG4B-associated genes across cancer lineages are OCM2, OR7G2, and TMEM207. Each is linked with ATG4B in more than 1 cancer types. Because this analysis shows association rather than direction, both ATG4B-to-partner and partner-to-ATG4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OCM2 grouped by ATG4B-low versus ATG4B-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG4B→partner) and Y-score (partner→ATG4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OCM2 →	+0.069	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR7G2 →	+0.018	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	TMEM207 →	+0.095	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	CXorf51A →	+0.055	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRAMEF11 →	+0.006	+5.662	<.001	.002	3	1
BLOOD_Leukemia	OR7C2 →	+0.026	+6.569	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

OCM2 by ATG4B expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →