ATG3

Across TCGA patient cohorts, ATG3 mutation is significantly associated with the RNA expression of many other genes, with 1,493 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATG3-associated genes across cancer lineages are RNA5SP75, IGHVIV-44-1, and CCDC121P1. Each is linked with ATG3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATG3-to-partner and partner-to-ATG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP75 grouped by ATG3-low versus ATG3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG3→partner) and Y-score (partner→ATG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP75 →	+0.565	+5.103	<.001	.008	3	2
CESC	IGHVIV-44-1 →	+0.437	+5.201	<.001	.007	3	2
CESC	CCDC121P1 →	+0.130	+5.103	.009	.008	3	2
LUSC	RNA5SP497 →	+0.459	+5.191	<.001	.003	3	2
BRCA	MIR2392 →	+0.187	+7.471	<.001	.008	3	1
UCEC	DOC2B →	-1.209	-2.700	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,493 associations by consensus.

RNA5SP75 by ATG3 expression — CESC

Explore this box plot interactively →