ATG16L2

Across TCGA patient cohorts, ATG16L2 mutation is significantly associated with the RNA expression of many other genes, with 1,504 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATG16L2-associated genes across cancer lineages are PPP1R9A-AS1, USP9YP10, and TRAJ47. Each is linked with ATG16L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATG16L2-to-partner and partner-to-ATG16L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP1R9A-AS1 grouped by ATG16L2-low versus ATG16L2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG16L2→partner) and Y-score (partner→ATG16L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	PPP1R9A-AS1 →	+0.162	+4.133	<.001	.004	3	2
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	2
UCEC	TRAJ47 →	+0.383	+2.018	<.001	.002	3	2
UCEC	TRAJ12 →	+0.398	+1.996	.005	.001	3	2
UCEC	IGHD4-17 →	+0.508	+2.299	<.001	.004	3	2
BRCA	RNASEH1P1 →	+0.600	+3.905	.005	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,504 associations by consensus.

PPP1R9A-AS1 by ATG16L2 expression — CESC

Explore this box plot interactively →