ATG16L2

Across TCGA cell cohorts, ATG16L2 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ATG16L2-associated genes across cancer lineages are C18orf63, KRTAP5-4, and OR1L3. Each is linked with ATG16L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATG16L2-to-partner and partner-to-ATG16L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C18orf63 grouped by ATG16L2-low versus ATG16L2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG16L2→partner) and Y-score (partner→ATG16L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	C18orf63 →	+0.006	+5.369	<.001	.004	3	2
SOFT_TISSUE	KRTAP5-4 →	+0.032	+5.369	<.001	.004	3	2
OVARY	OR1L3 →	+0.050	+4.029	<.001	.009	3	2
SOFT_TISSUE	CST9L →	+0.028	+5.369	<.001	.004	3	1
SOFT_TISSUE	RLN3 →	+0.059	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR7E24 →	+0.029	+5.369	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

C18orf63 by ATG16L2 expression — SOFT_TISSUE

Explore this box plot interactively →