ATG14

Across TCGA patient cohorts, ATG14 mutation is significantly associated with the RNA expression of many other genes, with 4,230 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATG14-associated genes across cancer lineages are IGHD3-22, EIF3JP1, and RPS20P25. Each is linked with ATG14 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATG14-to-partner and partner-to-ATG14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD3-22 grouped by ATG14-low versus ATG14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG14→partner) and Y-score (partner→ATG14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGHD3-22 →	+1.192	+1.724	.001	<.001	3	2
UCEC	EIF3JP1 →	+0.253	+2.742	<.001	<.001	3	2
UCEC	RPS20P25 →	+0.077	+2.245	.005	.001	3	2
UCEC	RNU7-90P →	+0.183	+2.338	.001	.003	3	2
UCEC	RNA5SP419 →	+0.597	+1.939	<.001	<.001	3	2
HNSC	SNORD116-30 →	+0.521	+5.435	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,230 associations by consensus.

IGHD3-22 by ATG14 expression — UCEC

Explore this box plot interactively →