ATG14

Across TCGA patient cohorts, ATG14 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATG14-associated genes across cancer lineages are eEF2, EGFR_pY1068, and A-Raf_pS299. Each is linked with ATG14 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATG14-to-partner and partner-to-ATG14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ATG14-low versus ATG14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG14→partner) and Y-score (partner→ATG14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.361	+3.321	.004	.009	3	1
UCEC	EGFR_pY1068 →	-0.300	-3.000	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.114	-2.700	.007	.006	3	1
UCEC	ERK2 →	+0.210	+1.662	.001	.011	3	1
UCEC	FoxM1 →	+0.188	+2.000	.040	.003	3	1
UCEC	GAPDH →	+0.471	+2.459	.013	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

eEF2 by ATG14 expression — UCEC

Explore this box plot interactively →