ATG10-IT1

Across TCGA patient cohorts, ATG10-IT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,745 significant associations in total. STAD shows the largest number of these associations.

The most reproducible ATG10-IT1-associated GO terms across cancer lineages are Negative regulation of mRNA metabolic process, Protein autoubiquitination, and RNA-templated DNA biosynthetic process. Each is linked with ATG10-IT1 in more than 13 cancer types. Because this analysis shows association rather than direction, both ATG10-IT1-to-partner and partner-to-ATG10-IT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of mRNA metabolic process grouped by ATG10-IT1-low versus ATG10-IT1-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG10-IT1→partner) and Y-score (partner→ATG10-IT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Negative regulation of mRNA metabolic process →	+0.044	+0.202	<.001	<.001	3	13
LAML	Protein autoubiquitination →	+0.047	+0.583	<.001	<.001	3	13
ESCA	RNA-templated DNA biosynthetic process →	+0.040	+0.143	<.001	<.001	2	14
STAD	Regulation of DNA repair →	+0.045	+0.105	<.001	<.001	3	13
STAD	Mismatch repair →	+0.041	+0.138	<.001	<.001	3	13
STAD	DNA biosynthetic process →	+0.049	+0.122	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,745 associations by consensus.

Negative regulation of mRNA metabolic process by ATG10-IT1 expression — ESCA

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