ATG10-IT1

Across TCGA pan-cancer cohorts, ATG10-IT1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated ATG10-IT1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher ATG10-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ATG10-IT1 expression acts as an unfavorable survival marker, although some lineages such as LIHC and CHOL show a favorable association.

UVM, UCEC, and TGCT are the cancer types where ATG10-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	II,III,IV	0.216	0.726	<.001	81	view →
UCEC	OS	Tertile	IV	0.344	0.802	<.001	72	view →
TGCT	OS	Tertile	All	0.906	0.993	.010	54	view →
CESC	OS	Tertile	III,IV	0.240	0.676	.042	36	view →
BLCA	DFS	Tertile	All	0.192	0.353	.028	33	view →
LUSC	DFS	Tertile	III,IV	0.324	0.813	.020	18	view →
LGG	DFS	Tertile	All	0.731	0.841	.011	12	view →
SKCM	OS	Tertile	IV	0.179	0.727	<.001	9	view →
PRAD	OS	Tertile	All	0.638	0.917	.026	6	view →
LIHC	DFS	Tertile	II,III,IV	0.740	0.165	.031	6	view →
CHOL	OS	Tertile	All	1.000	0.652	.041	3	view →
COAD	OS	Tertile	IV	0.900	0.405	.032	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

ATG10-IT1–UVM (OS)

Open the UVM breakdown →