ATF7IP

Across TCGA patient cohorts, ATF7IP mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATF7IP-associated genes across cancer lineages are beta-Catenin, 53BP1, and Dvl3. Each is linked with ATF7IP in more than 2 cancer types. Because this analysis shows association rather than direction, both ATF7IP-to-partner and partner-to-ATF7IP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, beta-Catenin grouped by ATF7IP-low versus ATF7IP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATF7IP→partner) and Y-score (partner→ATF7IP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	beta-Catenin →	+0.368	+1.440	.012	.022	3	3
UCEC	53BP1 →	+0.205	+1.700	.039	.040	3	3
UCEC	Dvl3 →	+0.107	+1.502	.044	.027	3	3
UCEC	eEF2 →	+0.217	+1.584	.037	.032	3	2
UCEC	FoxM1 →	+0.194	+1.906	.010	<.001	3	2
UCEC	MEK1 →	+0.357	+2.000	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

beta-Catenin by ATF7IP expression — UCEC

Explore this box plot interactively →