ATF7IP

Across TCGA pan-cancer cohorts, ATF7IP RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ATF7IP’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ATF7IP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ATF7IP is over-expressed in tumor.

KIRC, HNSC, and KIRP are the cancer types where ATF7IP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATF7IP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.527	<.001	12	view →
HNSC	Female	II,III,IV	+1.079	<.001	11	view →
KIRP	All	II,III,IV	+0.796	<.001	9	view →
LIHC	Female	II,III,IV	+1.158	<.001	7	view →
LUSC	Female	All	+1.082	<.001	6	view →
LUAD	Male	All	+0.651	<.001	6	view →
BLCA	All	All	+0.505	.005	6	view →
STAD	All	II,III,IV	+0.663	.006	4	view →
COAD	Male	All	+0.444	.007	4	view →
CHOL	All	All	+2.168	<.001	3	view →
ESCA	Female	All	+0.803	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ATF7IP–KIRC

Open the KIRC breakdown →