ATF7IP

Across TCGA cell cohorts, ATF7IP mutation is significantly associated with the RNA expression of many other genes, with 1,148 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATF7IP-associated genes across cancer lineages are OR2H1, OR11H2, and OR2L8. Each is linked with ATF7IP in more than 1 cancer types. Because this analysis shows association rather than direction, both ATF7IP-to-partner and partner-to-ATF7IP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2H1 grouped by ATF7IP-low versus ATF7IP-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATF7IP→partner) and Y-score (partner→ATF7IP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR2H1 →	+0.087	+2.352	.002	.002	3	2
LUNG_NSCLC_LUAD	OR11H2 →	+0.007	+2.481	.007	.001	3	2
CNS	OR2L8 →	+0.019	+4.169	<.001	.008	3	2
LARGE_INTESTINE	OPTN →	-0.967	-2.459	.001	.006	3	2
LARGE_INTESTINE	ACVR1C →	+0.519	+3.321	.003	.003	3	2
LARGE_INTESTINE	CD164L2 →	+0.623	+2.244	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,148 associations by consensus.

OR2H1 by ATF7IP expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →