Across TCGA patient cohorts, ATF6B mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATF6B-associated genes across cancer lineages are Ku80, 4E-BP1, and Cyclin-B1. Each is linked with ATF6B in more than 1 cancer types. Because this analysis shows association rather than direction, both ATF6B-to-partner and partner-to-ATF6B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATF6B→partner) and Y-score (partner→ATF6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.245	+2.009	.010	.017	3	2
SKCM	4E-BP1 →	+0.389	+3.459	.010	.005	3	2
UCEC	Cyclin-B1 →	+0.510	+1.906	.024	.016	3	2
UCEC	HER3_pY1289 →	+0.079	+2.999	.023	.035	3	1
UCEC	IGFBP2 →	-0.640	-1.906	.014	.016	3	1
UCEC	MAPK_pT202_Y204 →	-0.372	-1.700	.049	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

ATF6B survival (RNA) · tumor vs normal (RNA) · all ATF6B data types