Across TCGA pan-cancer cohorts, ATF6B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ATF6B’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ATF6B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ATF6B is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.
HNSC, LIHC, and KIRC are the cancer types where ATF6B tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATF6B RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.