Across TCGA cell cohorts, ATF6B mutation is significantly associated with the drug of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATF6B-associated genes across cancer lineages are Ispinesib Mesylate, GSK429286A, and Y-39983. Each is linked with ATF6B in more than 1 cancer types. Because this analysis shows association rather than direction, both ATF6B-to-partner and partner-to-ATF6B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATF6B→partner) and Y-score (partner→ATF6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Ispinesib Mesylate →	+0.692	+2.652	.034	.045	3	1
LARGE_INTESTINE	GSK429286A →	+0.390	+2.652	.011	.045	3	1
LARGE_INTESTINE	Y-39983 →	+0.500	+2.652	.020	.045	3	1
LARGE_INTESTINE	GSK690693 →	+0.674	+2.791	.007	.028	3	1
LARGE_INTESTINE	AT7867 →	+0.554	+2.652	.020	.045	3	1
LARGE_INTESTINE	FY012 →	+0.624	+2.649	.001	.046	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

ATF6B survival (RNA) · tumor vs normal (RNA) · all ATF6B data types