ATF6

Across TCGA patient cohorts, ATF6 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,744 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ATF6-associated proteins across cancer lineages are SNX27, HDGF, and TIPRL. Each is linked with ATF6 in more than 4 cancer types. Because this analysis shows association rather than direction, both ATF6-to-partner and partner-to-ATF6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ATF6 versus SNX27 in UCEC, with a Pearson correlation of 0.42.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ATF6→partner) and Y-score (partner→ATF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNX27 →	+0.268	+0.641	<.001	<.001	3	5
UCEC	HDGF →	+0.345	+0.459	<.001	<.001	3	5
COAD	TIPRL →	+0.240	+0.490	<.001	<.001	3	5
HNSC	POGK →	+0.369	+0.592	<.001	.001	3	5
HNSC	PRUNE1 →	+0.402	+0.784	<.001	<.001	3	5
BRCA	OTUD7B →	+0.243	+0.344	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,744 associations by consensus.

ATF6 vs SNX27 — UCEC

Explore this scatter interactively →