ATF6

Across TCGA pan-cancer cohorts, ATF6 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ATF6’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ATF6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ATF6 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, LIHC, and KICH are the cancer types where ATF6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATF6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.492	<.001	10	view →
LIHC	Male	All	+1.051	<.001	9	view →
KICH	Female	II,III,IV	−1.561	<.001	7	view →
BRCA	All	III,IV	+0.587	<.001	6	view →
BLCA	Female	All	+0.507	.002	6	view →
STAD	All	All	+0.471	<.001	6	view →
THCA	All	All	−0.343	.001	6	view →
KIRC	All	II,III,IV	−0.337	.003	6	view →
CHOL	All	All	+1.564	<.001	3	view →
COAD	Male	All	+0.312	<.001	3	view →
LUAD	All	All	+0.262	.001	3	view →
ESCA	All	All	+0.472	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ATF6–HNSC

Open the HNSC breakdown →