ATF6

Across TCGA patient cohorts, ATF6 mutation is significantly associated with the RNA expression of many other genes, with 3,333 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATF6-associated genes across cancer lineages are MIR3927, MCMBP, and PRIM1. Each is linked with ATF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATF6-to-partner and partner-to-ATF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3927 grouped by ATF6-low versus ATF6-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATF6→partner) and Y-score (partner→ATF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR3927 →	+0.327	+4.433	<.001	.007	3	2
UCEC	MCMBP →	+0.369	+1.741	.003	<.001	3	2
UCEC	PRIM1 →	+0.518	+1.720	.001	<.001	3	2
UCEC	HNRNPCP1 →	+0.494	+3.247	<.001	<.001	3	2
UCEC	BOP1 →	+0.363	+2.247	.006	.001	3	2
UCEC	BAG3 →	+0.575	+2.146	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,333 associations by consensus.

MIR3927 by ATF6 expression — BLCA

Explore this box plot interactively →