ATF6

Across TCGA patient cohorts, ATF6 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATF6-associated genes across cancer lineages are YB-1, EGFR_pY1068, and EGFR. Each is linked with ATF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATF6-to-partner and partner-to-ATF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YB-1 grouped by ATF6-low versus ATF6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATF6→partner) and Y-score (partner→ATF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	YB-1 →	+0.252	+3.012	.024	.018	3	1
UCEC	EGFR_pY1068 →	-0.229	-1.847	.004	.007	3	1
UCEC	EGFR →	-0.166	-1.880	.001	.014	3	1
UCEC	eIF4E →	+0.199	+2.920	.003	<.001	3	1
UCEC	ERK2 →	+0.151	+2.584	.015	.010	3	1
UCEC	INPP4B →	-0.233	-2.415	.026	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

YB-1 by ATF6 expression — SKCM

Explore this box plot interactively →