ATF6

Across TCGA cell cohorts, ATF6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,330 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ATF6-associated GO terms across cancer lineages are ER-nucleus signaling pathway, ERAD pathway, and ATF6-mediated unfolded protein response. Each is linked with ATF6 in more than 16 cancer types. Because this analysis shows association rather than direction, both ATF6-to-partner and partner-to-ATF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-nucleus signaling pathway grouped by ATF6-low versus ATF6-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATF6→partner) and Y-score (partner→ATF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ER-nucleus signaling pathway →	+0.104	+0.779	<.001	<.001	3	17
PANCREAS	ERAD pathway →	+0.097	+0.914	<.001	<.001	3	16
URINARY_TRACT	ATF6-mediated unfolded protein response →	+0.198	+1.083	<.001	<.001	3	16
BLOOD_Myeloma	Regulation of ATF6-mediated unfolded protein response →	+0.188	+1.015	.003	.001	3	15
PANCREAS	Response to endoplasmic reticulum stress →	+0.083	+0.856	.002	.001	3	14
BLOOD_Myeloma	Protein deglycosylation →	+0.145	+0.956	.001	.006	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,330 associations by consensus.

ER-nucleus signaling pathway by ATF6 expression — LARGE_INTESTINE

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