ATF6

Across TCGA cell cohorts, ATF6 mutation is significantly associated with the RNA expression of many other genes, with 110 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATF6-associated genes across cancer lineages are OR6B3, SLC15A5, and DPPA2. Each is linked with ATF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATF6-to-partner and partner-to-ATF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6B3 grouped by ATF6-low versus ATF6-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATF6→partner) and Y-score (partner→ATF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR6B3 →	+0.136	+6.022	<.001	.001	3	1
SKIN	SLC15A5 →	+0.063	+4.977	<.001	.007	3	1
BLOOD_Lymphoma	DPPA2 →	+0.218	+4.523	<.001	.004	3	1
LARGE_INTESTINE	PSMC6 →	+0.564	+3.299	<.001	.004	3	1
LARGE_INTESTINE	SF3B6 →	+0.579	+3.212	.001	.006	3	1
LARGE_INTESTINE	SOCS2 →	+1.671	+3.212	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 110 associations by consensus.

OR6B3 by ATF6 expression — SKIN

Explore this box plot interactively →