ATF5

Across TCGA patient cohorts, ATF5 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATF5-associated genes across cancer lineages are MSH2, EGFR_pY1068, and MEK1. Each is linked with ATF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATF5-to-partner and partner-to-ATF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by ATF5-low versus ATF5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATF5→partner) and Y-score (partner→ATF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.408	-2.973	.001	.035	3	2
UCEC	EGFR_pY1068 →	-0.278	-3.000	.044	.036	3	1
UCEC	MEK1 →	+0.605	+3.169	.002	.020	3	1
UCEC	Myosin-IIa →	+0.318	+3.177	.001	.010	3	1
UCEC	Notch1 →	+0.290	+2.820	<.001	.035	3	1
UCEC	p70-S6K_pT389 →	-0.264	-3.169	.011	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

MSH2 by ATF5 expression — UCEC

Explore this box plot interactively →