ATF5

Across TCGA cell cohorts, ATF5 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. CNS shows the largest number of these associations.

The most reproducible ATF5-associated genes across cancer lineages are OOSP4A, C12orf40, and KLHL40. Each is linked with ATF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATF5-to-partner and partner-to-ATF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OOSP4A grouped by ATF5-low versus ATF5-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATF5→partner) and Y-score (partner→ATF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OOSP4A →	+0.043	+5.321	<.001	.005	3	2
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	2
BLOOD_Lymphoma	KLHL40 →	+0.013	+5.209	<.001	.005	3	2
CNS	SLC17A2 →	+0.028	+4.981	<.001	.008	3	1
CNS	TAAR6 →	+0.022	+5.321	<.001	.005	3	1
CNS	ASB10 →	+0.041	+4.981	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

OOSP4A by ATF5 expression — CNS

Explore this box plot interactively →