ATF4P4

Across TCGA pan-cancer cohorts, ATF4P4 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ATF4P4 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ATF4P4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ATF4P4 expression acts as an unfavorable survival marker, although some lineages such as SKCM and GBM show a favorable association.

HNSC, SKCM, and CESC are the cancer types where ATF4P4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.029	0.726	<.001	36	view →
SKCM	DFS	Median	III,IV	1.000	0.218	.005	16	view →
CESC	OS	Median	III,IV	0.068	0.756	<.001	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
GBM	DFS	Median	All	1.000	0.192	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ATF4P4–HNSC (OS)

Open the HNSC breakdown →