ATF3

Across TCGA patient cohorts, ATF3 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATF3-associated genes across cancer lineages are FOXO3a_pS318_S321, eEF2, and ERK2. Each is linked with ATF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATF3-to-partner and partner-to-ATF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by ATF3-low versus ATF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATF3→partner) and Y-score (partner→ATF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.134	-2.115	.013	.019	3	2
UCEC	eEF2 →	+0.318	+2.999	.042	.035	3	1
UCEC	ERK2 →	+0.217	+2.807	.009	.003	3	1
UCEC	ETS-1 →	+0.285	+2.115	.040	.019	3	1
UCEC	GAPDH →	+0.604	+2.115	.010	.019	3	1
UCEC	JNK2 →	+0.267	+3.179	.002	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

FOXO3a_pS318_S321 by ATF3 expression — UCEC

Explore this box plot interactively →