ATF3

Across TCGA pan-cancer cohorts, ATF3 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ATF3’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where ATF3 RNA is repressed in tumor relative to normal tissue. In most cancer types ATF3 is over-expressed in tumor, although a few such as BLCA and KIRC show the opposite, repressed pattern.

BLCA, KIRC, and KICH are the cancer types where ATF3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATF3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	−2.412	<.001	12	view →
KIRC	All	III,IV	−1.602	<.001	11	view →
KICH	All	III,IV	−3.389	<.001	9	view →
KIRP	Male	All	−2.081	<.001	9	view →
UCEC	All	IV	−5.115	<.001	8	view →
LUAD	Female	All	−1.699	<.001	8	view →
LUSC	Female	II,III,IV	−2.142	<.001	7	view →
BRCA	All	III,IV	−2.526	<.001	6	view →
LIHC	Female	All	−1.253	<.001	4	view →
THCA	Female	All	−1.509	<.001	3	view →
PRAD	All	All	−0.733	.041	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ATF3–BLCA

Open the BLCA breakdown →