ATE1

Across TCGA patient cohorts, ATE1 mutation is significantly associated with the RNA expression of many other genes, with 1,651 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATE1-associated genes across cancer lineages are RN7SKP61, BNIP3P3, and DDR1-DT. Each is linked with ATE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATE1-to-partner and partner-to-ATE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP61 grouped by ATE1-low versus ATE1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATE1→partner) and Y-score (partner→ATE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RN7SKP61 →	+0.144	+7.954	<.001	.008	3	2
PRAD	BNIP3P3 →	+0.089	+7.939	<.001	.008	3	2
UCEC	DDR1-DT →	+0.035	+2.371	.008	<.001	3	2
SKCM	OR4K12P →	+0.021	+4.475	<.001	.005	3	2
SKCM	SNRPD2P2 →	+0.133	+3.300	<.001	.004	3	2
SKCM	TOMM22P5 →	+0.185	+3.878	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,651 associations by consensus.

RN7SKP61 by ATE1 expression — HNSC

Explore this box plot interactively →