ATAD2B

Across TCGA pan-cancer cohorts, ATAD2B RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ATAD2B data layer compared with 9 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ATAD2B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ATAD2B expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

ACC, HNSC, and KIRP are the cancer types where ATAD2B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.355	0.798	<.001	142	view →
HNSC	OS	Quartile	All	0.858	0.680	.001	67	view →
KIRP	OS	Median	II,III,IV	0.459	0.932	.002	63	view →
MESO	DFS	Median	II,III,IV	0.296	0.447	.010	36	view →
UVM	DFS	Quartile	III,IV	0.182	0.814	.001	35	view →
GBM	DFS	Median	All	0.397	0.183	.001	21	view →
LIHC	DFS	Quartile	All	0.415	0.629	<.001	21	view →
READ	OS	Median	II,III,IV	0.783	0.326	.007	21	view →
UCS	DFS	Tertile	IV	0.832	0.364	.024	18	view →
KIRC	DFS	Tertile	III,IV	0.925	0.713	.013	18	view →
LGG	OS	Quartile	All	0.380	0.822	<.001	18	view →
THYM	OS	Tertile	All	1.000	0.809	.018	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ATAD2B–ACC (DFS)

Open the ACC breakdown →